Because YESCARTA is a treatment that works on your immune system, there is a risk that your immune system may become overactive and affect the rest of your body in unwanted ways. You can learn about the
possible side effects of YESCARTA by reading the Important Safety Information.
CRS and Neurotoxicity can become life-threatening and can lead to death. Call or see your healthcare provider or get emergency help right away if you get any of the following:
Fever (100.4°F/38°C or higher)
Difficulty breathing
Chills or shaking chills
Confusion
Dizziness or lightheadedness
Severe nausea, vomiting, or diarrhea
Fast or irregular heartbeat
Severe fatigue or weakness
It is important to tell your healthcare provider that you received YESCARTA and to show them your YESCARTA Patient Wallet Card. Your healthcare provider may
give you other medicines to treat your side effects.
The most common side effects of YESCARTA include:
Fever (100.4°F/38°C or higher)
Low white blood cells (can occur with a fever)
Low red blood cells
Low blood pressure (dizziness or lightheadedness, headache, feeling tired, short of breath)
Fast heartbeat
Confusion
Difficulty speaking or slurred speech
Nausea
Diarrhea
YESCARTA may increase your risk of getting cancers including certain types of blood cancers. Your healthcare provider should monitor you for this.
These are not all the possible side effects of YESCARTA. It’s important to talk to your treatment team about how you are feeling, and let them know if you notice any symptoms. Each
person's experience and potential side effects will be different.
How will the treatment team manage side effects and keep me safe?
Your safety and care are top priority. There will be multiple safety measures in place throughout your YESCARTA treatment experience:
What is my role in managing side effects?
Both patients and caregivers play an important role during CAR T treatment. See below for what you can do and how your responsibilities may shift throughout treatment.
Remember that you can always ask your treatment team if you have questions about side effects and how to look for them.
During YESCARTA infusion and close monitoring
To help prepare for your CAR T-cell infusion, your treatment team may give you premedications.
You will need to stay at the treatment center for at least 1 week after the infusion in case serious side effects happen. During this time, you will be under the care of your treatment team. Serious side
effects are most likely in the first few weeks after infusion.
Your treatment team is well equipped to manage and treat side effects. They will regularly complete
health checks? and ask you to do
some simple tasks? to identify and track any symptoms. If needed, they may treat CRS or neurotoxicity with corticosteroids or other medications.
Your treatment team is well equipped to manage and treat side effects. They will regularly complete
health checks? and ask you to do
some simple tasks? to identify and track any symptoms. If needed, they may treat CRS or neurotoxicity with corticosteroids or other medications.
What you can do
Proactively tell the treatment team if you notice any changes in how you're feeling. Caregivers may be the first to notice side effects, as some symptoms can be difficult for patients to recognize by
themselves.
The treatment team can also answer any questions you may have about side effects and how to look for them.
Learn more about what to expect and how to prepare for this step on the Receiving YESCARTA page.
“Every day while I was in the hospital, each shift of nurses would have me write my name on a piece of paper, ask me what day it was, and ask me to identify five different objects in my room.”
MargaretYESCARTA Patient
This testimonial is representative of the patient’s own experience. Individual treatment results and experience may vary.
This testimonial is representative of the patient’s own experience. Individual treatment results and experience may vary.
During continued monitoring
After the first week, you may be able to leave the treatment center but you will still need to stay close to a certified healthcare facility until at least 4 weeks after infusion, so you can get help quickly if any side effects occur. Your treatment team will let you know where this continued monitoring will take place.
What you can do
Follow your treatment team’s instructions for monitoring for signs and symptoms of side effects. You will be responsible for monitoring side effects once you’ve left the center.
Notify your treatment team immediately if you notice any changes. Receiving medical attention right away may keep side effects from becoming more serious.
It is important to tell any healthcare providers you visit that you received YESCARTA, and have your treatment team’s contact information on hand.
Learn more about what to expect and how to prepare for this step on the Receiving YESCARTA page.
“I was hyper-aware of every little change my body was going through, and it was a little overwhelming! My mom and I had a detailed schedule for when to take meds, blood pressure, and temperature. We had alarms on our phones and a checklist to make sure we didn't miss anything.”
LayraYESCARTA Patient
This testimonial is representative of the patient’s own experience. Individual treatment results and experience may vary.
This testimonial is representative of the patient’s own experience. Individual treatment results and experience may vary.
During recovery at home
When the treatment team thinks you are ready—at least 4 weeks after infusion—you'll no longer be required to stay near a certified healthcare facility. If you had to travel for treatment, this means you can now return home. You may also start
returning to your local oncologist for follow-up appointments.
What you can do
Continue to look out for side effects and talk to your healthcare teams about how you are feeling. Make sure to attend follow-up appointments. If you miss an appointment, it’s important to reschedule as soon as possible.
You should continue to tell any healthcare providers you visit that you received YESCARTA.
Learn more about what to expect and how to prepare for this step on the Receiving YESCARTA page.
“When we were in the hospital, if something went wrong, I could just stick my head out the door and a whole medical team would be there. At home, we don’t have that. But I had the numbers for emergency help and knowing that was available to me made me feel better.”
SkipYESCARTA Caregiver
This testimonial is representative of the caregiver’s own experience. Individual treatment results and experience may vary.
This testimonial is representative of the caregiver’s own experience. Individual treatment results and experience may vary.
Patient and caregiver perspectives
This testimonial is representative of patients’ and caregivers’ own experiences. Individual treatment results and experience may vary.
Monitoring side effects
Learn more about what side effect monitoring was like for YESCARTA patients and caregivers
In order to provide YESCARTA, cancer treatment centers must first be certified. Certified treatment centers have specifically-trained medical staff, strict treatment protocols, and safety measures in place
for CAR T-cell therapy. These centers are often first to use best care practices learned through research.
Certified treatment centers are sometimes known as authorized treatment centers, or certified healthcare facilities.
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Certified treatment center locator tool
There are over 120 cancer centers certified to provide YESCARTA throughout the US. When choosing a location, consider that you will need to stay close to a center for at least 4 weeks after receiving YESCARTA.
You can use the locator tool to find and learn about nearby treatment centers and their teams.
Information on new centers (where available) will be added on an ongoing basis. You can also contact your treatment team to learn more.
Traveling From
Typical driving times around your location
1 hour2 hours
Certified treatment centers (also called Authorized Treatment Centers) are independent facilities certified to dispense Kite CAR T therapies. Choice of a certified treatment center is within the sole discretion of the physician and patient. Kite does not endorse any individual treatment sites. Insurance coverage should be considered when reviewing certified treatment center options.
CRS happens when your immune system becomes overactive.
After infusion, when the modified T cells recognize and kill cancer cells, they may release proteins called cytokines.
A buildup of cytokines can lead to symptoms including:
fever
chills
rapid heart rate
low blood pressure
low blood oxygen level
CRS can last for about a week and typically occurs in the first few days after infusion, when you are staying at the treatment center under the care of the treatment team.
YESCARTA is a prescription medicine used to treat two types of non-Hodgkin
lymphoma ...
Important Safety Information
What is the most important information I should know about YESCARTA? YESCARTA may cause side effects that
are life-threatening and can lead to death ...
YESCARTA® is a prescription medicine used to treat two types of non-Hodgkin lymphoma:
large B-cell lymphoma when your first treatment did not work or your cancer returned within a year of first treatment, OR when at least two kinds of treatment have failed to control your cancer.
follicular lymphoma when at least two kinds of treatment have failed to control your cancer.
YESCARTA is different than other cancer medicines because it is made from your own white blood cells, which have been modified to recognize and attack your lymphoma cells.
Important Safety Information
What is the most important information I should know about YESCARTA?
YESCARTA may cause side effects that are life-threatening and can lead to death. Call or see your healthcare provider or get emergency help right away if you get any of the following:
Fever (100.4°F/38°C or higher)
Difficulty breathing
Chills or shaking chills
Confusion
Dizziness or lightheadedness
Severe nausea, vomiting, or diarrhea
Fast or irregular heartbeat
Severe fatigue or weakness
It is important to tell your healthcare provider that you received YESCARTA and to show them your YESCARTA Patient Wallet Card. Your healthcare provider may give you other medicines to treat your side
effects.
Before getting YESCARTA, tell your healthcare provider about all your medical problems, including if you have or have had:
Neurologic problems (such as seizures, stroke, or memory loss)
Lung or breathing problems
Heart problems
Liver problems
Kidney problems
A recent or active infection
Tell your healthcare provider about all the medications you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
How will I receive YESCARTA?
Since YESCARTA is made from your own white blood cells, your blood will be collected by a process called “leukapheresis” (loo-kah-fur-ee-sis), which will concentrate your white blood cells.
Your blood cells will be sent to a manufacturing center to make your YESCARTA.
Before you get YESCARTA, you will get 3 days of chemotherapy to prepare your body.
When your YESCARTA is ready, your healthcare provider will give it to you through a catheter placed into your vein (intravenous infusion). The infusion usually takes less than 30 minutes.
You will be monitored where you received your treatment daily for at least 7 days after the infusion.
You should plan to stay close to a certified healthcare facility for at least 4 weeks after getting YESCARTA. Your healthcare provider will help you with any side effects that may occur.
You may be hospitalized for side effects and your healthcare provider will discharge you if your side effects are under control, and it is safe for you to leave the hospital.
Your healthcare provider will want to do blood tests to follow your progress. It is important that you do have your blood tested. If you miss an appointment, call your healthcare provider as soon
as possible to reschedule.
What should I avoid after receiving YESCARTA?
Do not drive, operate heavy machinery, or do other dangerous things for 8 weeks after you get YESCARTA because the treatment can cause sleepiness, confusion, weakness, and temporary memory and
coordination problems.
Do not donate blood, organs, tissues, or cells for transplantation.
What are the possible or reasonably likely side effects of YESCARTA?
The most common side effects of YESCARTA include:
Fever (100.4°F/38°C or higher)
Low white blood cells (can occur with a fever)
Low red blood cells
Low blood pressure (dizziness or lightheadedness, headache, feeling tired, short of breath)
Fast heartbeat
Confusion
Difficulty speaking or slurred speech
Nausea
Diarrhea
YESCARTA may increase your risk of getting cancers including certain types of blood cancers. Your healthcare provider should monitor you for this.
These are not all the possible side effects of YESCARTA. Call your healthcare provider about any side effects that concern you. You are encouraged to report negative side effects of prescription drugs
to the FDA. Visit www.fda.gov/medwatch or call
1-800-FDA-1088.
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of the screen.
Some simple tasks your treatment team might ask you to do:
Write something, like a standard sentence
Say something, like naming the date and location you are in, pointing to and naming objects in the room, counting backwards from 100 by increments of 10
Follow a simple instruction, like holding up two fingers
